血小板 CD40 配体（CD154）在急性冠状动脉综合征中的作用。

The role of platelets CD40 ligand (CD154) in acute coronary syndromes.

机构信息

Internal Medicine Department, Faculty of Medicine, El-Minia University, Egypt.

出版信息

Thromb Res. 2009 Dec;124(6):683-8. doi: 10.1016/j.thromres.2009.06.028. Epub 2009 Aug 4.

DOI:10.1016/j.thromres.2009.06.028

PMID:19656553

Abstract

BACKGROUND

Despite of the proof of the biological function of CD154 on platelets, there has been little information about its role either in patients with stable angina or in those with acute coronary syndrome (ACS).

OBJECTIVE

This study aimed to investigate the expression of CD154 on platelets and its role in ACS.

METHODS

The study included 50 patients with ACS (24 patients with acute myocardial infarction (AMI) and 26 patients with unstable angina (UA)), 20 patients with stable angina (SA) and 18 healthy volunteers. CD154 and CD62 expression on platelets were analyzed by flow cytometry. Their relations to the clinical and laboratory data were assessed in the studied group.

RESULTS

Patients with AMI and UA had higher levels of platelets CD154 and CD62 as compared to those with SA and among patients with AMI, UA and SA versus healthy volunteers. Platelets CD154 showed significant positive correlations with the studied pro-inflammatory markers (Ox-LDL, CRP and fibrinogen), segmental wall motion score and the studied risk factors. There were significant negative correlations between platelet CD154 and serum nitric oxide among patients.

CONCLUSIONS

CD154 may be used as a marker of thrombo-embolic events. Nitric oxide may have an anti-atherogenic effect. There is an association between platelet activation and severity of coronary artery disease among patients with ACS.

摘要

背景

尽管已有证据表明 CD154 在血小板上具有生物学功能，但关于其在稳定性心绞痛或急性冠脉综合征（ACS）患者中的作用的信息却很少。

目的

本研究旨在探讨血小板 CD154 的表达及其在 ACS 中的作用。

方法

该研究纳入了 50 例 ACS 患者（24 例急性心肌梗死（AMI）患者和 26 例不稳定型心绞痛（UA）患者）、20 例稳定性心绞痛（SA）患者和 18 名健康志愿者。通过流式细胞术分析血小板上的 CD154 和 CD62 的表达，并评估其与研究组中临床和实验室数据的关系。

结果

与 SA 患者相比，AMI 和 UA 患者的血小板 CD154 和 CD62 水平更高，在 AMI、UA 和 SA 患者与健康志愿者之间也更高。血小板 CD154 与研究的促炎标志物（Ox-LDL、CRP 和纤维蛋白原）、节段性壁运动评分和研究的危险因素呈显著正相关。患者的血小板 CD154 与血清一氧化氮之间存在显著负相关。