孕前及孕早期子宫血流与阻力指数之间的关系。
Relationship between prepregnancy and early pregnancy uterine blood flow and resistance index.
作者信息
Hale Sarah A, Schonberg Adrienne, Badger Gary J, Bernstein Ira M
机构信息
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, Vermont 05404, USA.
出版信息
Reprod Sci. 2009 Nov;16(11):1091-6. doi: 10.1177/1933719109341843. Epub 2009 Aug 5.
We evaluated the relationship between prepregnancy and early pregnancy uterine blood flow (UBF) and resistance index (RI). Nineteen nulliparous participants were studied during cycle day 8 + 4, and early pregnancy (13.4 + 1.6 weeks). Color Doppler ultrasound of both uterine arteries and maternal heart was performed to calculate uterine RI, volumetric UBF, and cardiac output (CO), respectively. We observed a strong negative association of uterine RI with prepregnancy UBF (r = -.82, P < .001) that weakened, but remained significant in early pregnancy (r =-.48, P = .04). Prepregnancy uterine index (UBF/CO) was significantly associated with early pregnancy uterine index; r = .48, P = .04). There was also a trend associating prepregnancy and early pregnancy volumetric UBF (r = .44, P = .068). Prepregnancy UBF may be a determinant of early pregnancy UBF and UBF may have independent value as a predictor of adverse pregnancy outcome.
我们评估了孕前及孕早期子宫血流（UBF）与阻力指数（RI）之间的关系。对19名未生育的参与者在月经周期第8±4天以及孕早期（13.4±1.6周）进行了研究。分别对双侧子宫动脉及母体心脏进行彩色多普勒超声检查，以计算子宫RI、子宫血流容积（UBF）和心输出量（CO）。我们观察到子宫RI与孕前UBF呈强烈负相关（r = -0.82，P < 0.001），这种相关性在孕早期有所减弱，但仍具有显著性（r = -0.48，P = 0.04）。孕前子宫指数（UBF/CO）与孕早期子宫指数显著相关；r = 0.48，P = 0.04）。孕前和孕早期子宫血流容积也存在一定的相关性趋势（r = 0.44，P = 0.068）。孕前UBF可能是孕早期UBF的一个决定因素，并且UBF作为不良妊娠结局的预测指标可能具有独立价值。
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