McMillan Katherine A, Enns Murray W, Cox Brian James, Sareen Jitender
Department of Psychology, University of Regina, Regina, Saskatchewan.
Can J Psychiatry. 2009 Jul;54(7):477-86. doi: 10.1177/070674370905400709.
To examine the comorbidity of Axis I and II disorders within a community-based sample of adults with schizophrenia.
The study was conducted using data from the National Epidemiologic Survey of Alcohol and Related Conditions. A diagnosis of schizophrenia was based on respondents' self-report that they had been diagnosed by a health professional with schizophrenia or a psychotic illness or episode (SPIE). Axis I disorders and Axis II personality disorders (PDs) were assessed using the Alcohol Use Disorders and Associated Disabilities Interview Schedule. Mental and physical quality of life were assessed using the Medical Outcomes Study Short Form 12 questionnaire.
The prevalence of SPIE was 0.9%. We used multiple logistic regression to examine the association between the presence and absence of SPIE in Axis I and II mental disorders. Each of the Axis I and II mental disorders examined were significantly associated with a diagnosis of SPIE after controlling for age, sex, education, marital status, and household income.
Clinicians should be aware of the patterns and extent of psychiatric comorbidities that may exist in schizophrenia. Possible mechanisms of these associations are discussed.
在一个以社区为基础的成年精神分裂症患者样本中，研究轴I和轴II障碍的共病情况。
本研究使用了来自全国酒精及相关疾病流行病学调查的数据。精神分裂症的诊断基于受访者的自我报告，即他们曾被健康专业人员诊断为精神分裂症或精神疾病或发作（SPIE）。使用酒精使用障碍及相关残疾访谈表评估轴I障碍和轴II人格障碍（PDs）。使用医学结果研究简表12问卷评估心理和生理生活质量。
SPIE的患病率为0.9%。我们使用多元逻辑回归来研究轴I和轴II精神障碍中有无SPIE之间的关联。在控制了年龄、性别、教育程度、婚姻状况和家庭收入后，所检查的每一种轴I和轴II精神障碍都与SPIE诊断显著相关。
临床医生应了解精神分裂症中可能存在的精神共病模式和程度。讨论了这些关联的可能机制。
