角质形成细胞生长因子对胰腺癌进展的影响。
Influence of KGF on the progression of pancreatic cancer.
作者信息
Zang Xiao-Ping, Lerner Megan, Brackett Daniel, Pento J Thomas
机构信息
Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA.
出版信息
Anticancer Res. 2009 Aug;29(8):3417-20.
BACKGROUND
Keratinocyte growth factor (KGF increases the proliferation and motility of many epithelial cells and is known to be up-regulated in pancreatic cancer. The present study examined the hypothesis that KGF may initiate or enhance the progression of pancreatic cancer by increasing the proliferation and motility of pancreatic cancer cells.
MATERIALS AND METHODS
HPAF-II pancreatic cancer cell migration and proliferation was evaluated using a culture wounding assay 24 and 48 hours following KGF treatment. KGF receptor (KGFR) localization in these cells was established by immunohistochemistry.
RESULTS
KGF treatment significantly increased the proliferation and motility of the HPAF-II cells. In addition, KGF enhanced the motile morphology of these cancer cells.
CONCLUSION
The results of this study indicate that KGF has a rapid influence on the proliferation and motility of HPAF-II cells and suggest that KGF may be involved in the progression of pancreatic cancer.
背景
角质形成细胞生长因子（KGF）可增加多种上皮细胞的增殖和运动能力，且已知在胰腺癌中上调。本研究检验了KGF可能通过增加胰腺癌细胞的增殖和运动能力来启动或促进胰腺癌进展这一假说。
材料与方法
在KGF处理后24小时和48小时，使用培养伤口试验评估HPAF-II胰腺癌细胞的迁移和增殖。通过免疫组织化学确定这些细胞中KGF受体（KGFR）的定位。
结果
KGF处理显著增加了HPAF-II细胞的增殖和运动能力。此外，KGF增强了这些癌细胞的运动形态。
结论
本研究结果表明，KGF对HPAF-II细胞的增殖和运动能力有快速影响，并提示KGF可能参与胰腺癌的进展。
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