结构细胞外基质蛋白在膀胱尿路上皮癌中的作用（综述）
The role of structural extracellular matrix proteins in urothelial bladder cancer (review).
作者信息
Brunner Andrea, Tzankov Alexandar
机构信息
Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria.
出版信息
Biomark Insights. 2007 Nov 5;2:418-27. doi: 10.4137/bmi.s294.
Abstract
The extracellular matrix (ECM) plays a key role in the modulation of cancer cell invasion. In urothelial carcinoma of the bladder (UC) the role of ECM proteins has been widely studied. The mechanisms, which are involved in the development of invasion, progression and generalization, are complex, depending on the interaction of ECM proteins with each other as well as with cancer cells. The following review will focus on the pathogenetic role and prognostic value of structural proteins, such as laminins, collagens, fibronectin (FN), tenascin (Tn-C) and thrombospondin 1 (TSP1) in UC. In addition, the role of integrins mediating the interaction of ECM molecules and cancer cells will be addressed, since integrin-mediated FN, Tn-C and TSP1 interactions seem to play an important role during tumor cell invasion and angiogenesis.
摘要
细胞外基质（ECM）在调节癌细胞侵袭中起关键作用。在膀胱尿路上皮癌（UC）中，ECM蛋白的作用已得到广泛研究。参与侵袭、进展和转移发生的机制很复杂，这取决于ECM蛋白彼此之间以及与癌细胞的相互作用。以下综述将聚焦于层粘连蛋白、胶原蛋白、纤连蛋白（FN）、腱生蛋白（Tn-C）和血小板反应蛋白1（TSP1）等结构蛋白在UC中的致病作用和预后价值。此外，还将探讨介导ECM分子与癌细胞相互作用的整合素的作用，因为整合素介导的FN、Tn-C和TSP1相互作用似乎在肿瘤细胞侵袭和血管生成过程中发挥重要作用。
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