全氟辛烷磺酸/全氟辛酸对斑马鱼（Danio rerio）胚胎的毒理学研究
[Toxicological study of PFOS/PFOA to zebrafish (Danio rerio) embryos].
作者信息
Ye Lu, Wu Ling-Ling, Jiang Yu-Xi, Zhang Chao-Jie, Chen Ling
机构信息
College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resources Reuse, Tongji University, Shanghai 200092, China.
出版信息
Huan Jing Ke Xue. 2009 Jun 15;30(6):1727-32.
Acute toxicity of PFOS/PFOA to zebrafish (Danio rerio) and development effects to zebrafish embryo were examined using a zebrafish embryo test. PFOS/PFOA showed remarkably toxicity effects on zebrafish. The LC50 (48 h) values are 1 005 mg/L for PFOA, 107 mg/L for PFOS, while the LC50 (96 h) values are 499 mg/L for PFOA, 71 mg/L for PFOS. Moreover PFOS/PFOA inhibited embryo development, and caused embryo abnormality and death. After exposure to high concentration of PFOS (> 240 mg/L), cells in animal pole of embryos autolyzed to coagulate, which indicated PFOS caused cell membranes damage. The most sensitive endpoints for PFOS exposure is spinal column malformation, and the EC50 values is 9.14 mg/L. While for PFOA hatching (96 h) is the most sensitive, and the EC50 values is 328.0 mg/L. Both PFOS and PFOA retarded embryo development which indicates their development toxicity.
使用斑马鱼胚胎试验检测了全氟辛烷磺酸/全氟辛酸对斑马鱼（Danio rerio）的急性毒性以及对斑马鱼胚胎的发育影响。全氟辛烷磺酸/全氟辛酸对斑马鱼显示出显著的毒性作用。全氟辛酸的LC50（48小时）值为1005毫克/升，全氟辛烷磺酸的LC50（48小时）值为107毫克/升，而全氟辛酸的LC50（96小时）值为499毫克/升，全氟辛烷磺酸的LC50（96小时）值为71毫克/升。此外，全氟辛烷磺酸/全氟辛酸抑制胚胎发育，并导致胚胎异常和死亡。暴露于高浓度的全氟辛烷磺酸（>240毫克/升）后，胚胎动物极的细胞自溶凝结，这表明全氟辛烷磺酸导致细胞膜损伤。全氟辛烷磺酸暴露最敏感的终点是脊柱畸形，其EC50值为9.14毫克/升。而对于全氟辛酸，孵化（96小时）是最敏感的，其EC50值为328.0毫克/升。全氟辛烷磺酸和全氟辛酸均延缓胚胎发育，这表明它们具有发育毒性。
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