Jhunjhunwala Suchit, van Zelm Menno C, Peak Mandy M, Murre Cornelis
Division of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Cell. 2009 Aug 7;138(3):435-48. doi: 10.1016/j.cell.2009.07.016.
The adaptive immune system generates a specific response to a vast spectrum of antigens. This remarkable property is achieved by lymphocytes that each express single and unique antigen receptors. During lymphocyte development, antigen receptor coding elements are assembled from widely dispersed gene segments. The assembly of antigen receptors is controlled at multiple levels, including epigenetic marking, nuclear location, and chromatin topology. Here, we review recently uncovered mechanisms that underpin long-range genomic interactions and the generation of antigen receptor diversity.
适应性免疫系统对各种各样的抗原产生特异性反应。这一显著特性是由每个都表达单一且独特抗原受体的淋巴细胞实现的。在淋巴细胞发育过程中,抗原受体编码元件由广泛分散的基因片段组装而成。抗原受体的组装在多个层面受到控制,包括表观遗传标记、核定位和染色质拓扑结构。在这里,我们综述了最近发现的支撑远程基因组相互作用和抗原受体多样性产生的机制。