磷杂环丁烷修饰的铑催化剂：通过串联反应合成羟基官能化双环咪唑的一种新型选择性途径。

Phosphabarrelene-modified Rh-catalysts: a new and selective route towards hydroxy-functionalized bicyclic imidazoles via tandem reactions.

作者信息

Bäuerlein Patrick S, Gonzalez Ismael Arenas, Weemers Jarno J M, Lutz Martin, Spek Anthony L, Vogt Dieter, Müller Christian

机构信息

Schuit Institute of Catalysis, Laboratory for Homogeneous Catalysis, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.

出版信息

Chem Commun (Camb). 2009 Sep 7(33):4944-6. doi: 10.1039/b911612e. Epub 2009 Jul 23.

DOI:10.1039/b911612e

PMID:19668810

Abstract

8-Hydroxy-6-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine was formed selectively in high yields from N-(beta-methallyl)imidazole by a tandem hydroformylation-cyclization sequence, representing a novel one-pot catalytic synthesis of bicyclic imidazole derivatives.

摘要

通过氢甲酰化-环化串联反应，由N-（β-甲基烯丙基）咪唑以高收率选择性地生成8-羟基-6-甲基-5,6,7,8-四氢咪唑并[1,2-a]吡啶，这代表了一种新颖的双环咪唑衍生物的一锅法催化合成。