慢性移植物抗宿主病患者中类似皮肌炎的肌肉病理学表现
Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease.
作者信息
Allen Jeffrey A, Greenberg Steven A, Amato Anthony A
机构信息
Department of Neurology, Division of Neuromuscular Disease, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA.
出版信息
Muscle Nerve. 2009 Oct;40(4):643-7. doi: 10.1002/mus.21353.
Myositis is a rare complication of chronic graft-versus-host disease (cGVHD) following hematopoietic stem cell transplantation (HSCT). Almost all such patients have been reported to have polymyositis (PM). We describe clinical, pathologic, and molecular studies of 3 patients with cGVHD following allogeneic HSCT who developed myopathy. In each case, perifascicular atrophy, the pathognomonic histologic feature of dermatomyositis (DM), was observed.
肌炎是造血干细胞移植（HSCT）后慢性移植物抗宿主病（cGVHD）的一种罕见并发症。几乎所有这类患者均被报道患有多发性肌炎（PM）。我们描述了3例异基因HSCT后发生cGVHD并出现肌病的患者的临床、病理及分子研究情况。在每例患者中，均观察到束周萎缩，这是皮肌炎（DM）的特征性组织学表现。
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