Gagnon Jean-François, Vendette Mélanie, Postuma Ronald B, Desjardins Catherine, Massicotte-Marquez Jessica, Panisset Michel, Montplaisir Jacques
Centre d'étude du Sommeil et des Rythmes Biologiques, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
Ann Neurol. 2009 Jul;66(1):39-47. doi: 10.1002/ana.21680.
To investigate the frequency and subtypes of mild cognitive impairment (MCI) in idiopathic rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) in association with RBD.
One hundred and twelve subjects without dementia or major depression including 32 idiopathic RBD patients, 22 PD patients with polysomnography-confirmed RBD, 18 PD patients without RBD, and 40 healthy control subjects, underwent a comprehensive neuropsychological evaluation. We compared the proportion of patients with MCI between groups using standard diagnostic criteria.
MCI was found in 50% of idiopathic RBD patients and 73% of PD patients with RBD. In contrast, only 11% of PD patients without RBD and 8% of control subjects had MCI. The presence of MCI was significantly greater in idiopathic RBD patients and PD patients with RBD than in PD patients without RBD and control subjects. PD patients with RBD also performed worse than idiopathic RBD patients on neuropsychological tests assessing visuoconstructional and visuoperceptual abilities.
In both its association with PD and its idiopathic form, RBD is an important risk factor for MCI. Except for visuoconstructional and visuoperceptual problems, RBD may be an important determinant of cognitive impairment in PD. Ann Neurol 2009;66:39-47.
研究特发性快速眼动睡眠行为障碍（RBD）以及与RBD相关的帕金森病（PD）中轻度认知障碍（MCI）的发生率及亚型。
112名无痴呆或重度抑郁的受试者，包括32名特发性RBD患者、22名经多导睡眠图证实有RBD的PD患者、18名无RBD的PD患者以及40名健康对照者，接受了全面的神经心理学评估。我们使用标准诊断标准比较了各组中MCI患者的比例。
50%的特发性RBD患者和73%的有RBD的PD患者存在MCI。相比之下，无RBD的PD患者中只有11%，对照者中只有8%存在MCI。特发性RBD患者和有RBD的PD患者中MCI的发生率显著高于无RBD的PD患者和对照者。在评估视觉构建和视觉感知能力的神经心理学测试中，有RBD的PD患者表现也比特发性RBD患者差。
无论是与PD相关还是特发性形式，RBD都是MCI的重要危险因素。除视觉构建和视觉感知问题外，RBD可能是PD认知障碍的重要决定因素。《神经病学纪事》2009年；66:39 - 47。
