Kim Sang Kyu, Hwang Tae Yoon, Lee Kyeong Soo, Kang Pock Soo, Cho Hee Soon, Bae Young Kyung
Department of Preventive Medicine, Dongguk University, College of Medicine, Korea.
J Prev Med Public Health. 2009 Jul;42(4):261-6. doi: 10.3961/jpmph.2009.42.4.261.
The aim of this study is to examine the cognitive function change related to aging, the incidence of cognitive impairment, and the association between apolipoprotein E polymorphism and cognitive impairment through a follow-up of the elderly with normal cognitive ability at baseline.
Two hundred and fifteen subjects aged 65 and over were surveyed in February, 1998 (baseline survey), and their cognitive function was assessed again in 2003 (1st follow-up) and the once again in 2006 (2nd follow-up). Ninety one subjects completed all surveys up through the 2nd follow-up and their cognitive function scores using MMSE-K (Korean Version of the Mini-Mental State Examination) and the distribution of apolipoprotein E allele were analyzed.
The cognitive function scores decreased with aging and the difference between baseline and the 2nd follow-up scores of the study increased with the age group. The incidence rate of cognitive impairment through an 8-year follow-up was 38.5% and higher in older age groups. Age was the only significant factor for incidence of cognitive impairment, but there was no significant association between apolipoprotein E genotype and incidence of cognitive impairment.
The cognition of the elderly decreased with aging and the association of apolipoprotein E genotype with incidence of cognitive impairment was not significant in this study. To confirm the association between apolipoprotein E polymorphism and incidence of cognitive impairment further studies will be needed.
本研究旨在通过对基线认知能力正常的老年人进行随访，探讨与衰老相关的认知功能变化、认知障碍的发生率以及载脂蛋白E基因多态性与认知障碍之间的关联。
1998年2月对215名65岁及以上的受试者进行了调查（基线调查），并于2003年（第一次随访）和2006年（第二次随访）再次评估他们的认知功能。91名受试者完成了直至第二次随访的所有调查，并分析了他们使用MMSE-K（韩国版简易精神状态检查表）的认知功能得分以及载脂蛋白E等位基因的分布情况。
认知功能得分随年龄增长而下降，且研究中基线与第二次随访得分之间的差异随年龄组增加。8年随访期间认知障碍的发生率为38.5%，且在老年组中更高。年龄是认知障碍发生率的唯一显著因素，但载脂蛋白E基因型与认知障碍发生率之间无显著关联。
老年人的认知能力随年龄增长而下降，且本研究中载脂蛋白E基因型与认知障碍发生率之间的关联不显著。为确认载脂蛋白E基因多态性与认知障碍发生率之间的关联，还需要进一步研究。
