大剂量化疗联合自体外周血干细胞支持治疗复发性原发性产甲胎蛋白颅内生殖细胞瘤。
High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma.
作者信息
Ziske Carsten, Mezger Jörg, Jiménez Carlos, Kleinschmidt Rolf, Pels Hendrik, Schlegel Uwe, Schmidt-Wolf Ingo G H
机构信息
Medizinische Klinik und Poliklinik I, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
出版信息
Ger Med Sci. 2003 Jul 1;1:Doc03.
Abstract
We report of a 34-year old man with second intracranial relapse of a suprasellar germinoma. Despite of extensive pretreatment with radiation and conventional chemotherapy relapse occurred and was treated with sequential high-dose chemotherapy followed by transfusion of autologous peripheral stem cells. The high-dose chemotherapy course was complicated by refractory derailment of pineal gland insufficiency. The patient achieved a complete remission after high dose chemotherapy which lasted for 13 months. Subsequently, he developed a third relapse and died.
摘要
我们报告了一名34岁男性，其鞍上生殖细胞瘤出现第二次颅内复发。尽管在预处理阶段接受了广泛的放疗和传统化疗，但仍出现了复发，随后接受了序贯高剂量化疗，继之输注自体外周干细胞进行治疗。高剂量化疗过程因松果体功能不全的难治性紊乱而复杂化。患者在高剂量化疗后实现了完全缓解，缓解持续了13个月。随后，他出现了第三次复发并死亡。
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本文引用的文献
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High-dose chemotherapy with autologous stem-cell rescue in patients with recurrent and high-risk pediatric brain tumors.复发性和高危小儿脑肿瘤患者的大剂量化疗联合自体干细胞挽救治疗
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High-dose treatment with carboplatin, etoposide, and ifosfamide followed by autologous stem-cell transplantation in relapsed or refractory germ cell cancer: a phase I/II study. The German Testicular Cancer Cooperative Study Group.卡铂、依托泊苷和异环磷酰胺大剂量治疗后行自体干细胞移植治疗复发或难治性生殖细胞癌：一项I/II期研究。德国睾丸癌协作研究组。
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