High-dose chemotherapy with autologous peripheral blood stem cell support for recurrent primary AFP-producing intracranial germinoma.
作者信息
Ziske Carsten, Mezger Jörg, Jiménez Carlos, Kleinschmidt Rolf, Pels Hendrik, Schlegel Uwe, Schmidt-Wolf Ingo G H
机构信息
Medizinische Klinik und Poliklinik I, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
出版信息
Ger Med Sci. 2003 Jul 1;1:Doc03.
Abstract
We report of a 34-year old man with second intracranial relapse of a suprasellar germinoma. Despite of extensive pretreatment with radiation and conventional chemotherapy relapse occurred and was treated with sequential high-dose chemotherapy followed by transfusion of autologous peripheral stem cells. The high-dose chemotherapy course was complicated by refractory derailment of pineal gland insufficiency. The patient achieved a complete remission after high dose chemotherapy which lasted for 13 months. Subsequently, he developed a third relapse and died.
摘要
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