2型自身免疫性肝炎与丙型肝炎病毒感染

Type 2 autoimmune hepatitis and hepatitis C virus infection.

作者信息

Lenzi M, Ballardini G, Fusconi M, Cassani F, Selleri L, Volta U, Zauli D, Bianchi F B

机构信息

Istituto di Clinica Medica Generale e Terapia Medica, University of Bologna, Italy.

出版信息

Lancet. 1990 Feb 3;335(8684):258-9. doi: 10.1016/0140-6736(90)90070-l.

DOI:10.1016/0140-6736(90)90070-l

PMID:1967721

Abstract

The prevalence of serum antibodies to hepatitis C virus (HCV) was assessed by an enzyme-linked immunosorbent assay in 46 patients seropositive for liver-kidney microsomal antibody (anti-LKM1), the marker of autoimmune hepatitis type 2. 43 had chronic hepatitis (with histological confirmation in 34) and 3 were seropositive for anti-LKM1 without clinical or biochemical evidence of liver damage. The overall prevalence of anti-HCV was 78.2% or 86.1% in patients with chronic hepatitis--a similar prevalence to that reported in patients with chronic non A, non B posttransfusion hepatitis. HCV infection may lead to altered expression of the hepatocellullar LKM1 target antigen, with loss of tolerance and appearance of anti-LKM1 in serum.

摘要

通过酶联免疫吸附测定法评估了46例肝肾微粒体抗体（抗-LKM1，即2型自身免疫性肝炎的标志物）血清学阳性患者的丙型肝炎病毒（HCV）血清抗体流行情况。43例患有慢性肝炎（34例经组织学证实），3例抗-LKM1血清学阳性但无肝损伤的临床或生化证据。慢性肝炎患者中抗-HCV的总体流行率为78.2%或86.1%，这一流行率与慢性非甲非乙输血后肝炎患者中报告的流行率相似。HCV感染可能导致肝细胞LKM1靶抗原表达改变，从而失去耐受性并在血清中出现抗-LKM1。