肌萎缩侧索硬化症（ALS）患者疾病进展过程中适应性免疫中体液免疫反应的评估。
Evaluation of humoral immune response in adaptive immunity in ALS patients during disease progression.
作者信息
Saleh Islam A, Zesiewicz Theresa, Xie Yong, Sullivan Kelly L, Miller Amber M, Kuzmin-Nichols Nicole, Sanberg Paul R, Garbuzova-Davis Svitlana
机构信息
Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, USA.
出版信息
J Neuroimmunol. 2009 Oct 30;215(1-2):96-101. doi: 10.1016/j.jneuroim.2009.07.011. Epub 2009 Aug 14.
In ALS, evidence suggests immune reactions in disease pathogenesis. Although immunological changes point to adaptive immune response, whether humoral or cellular response dominates during disease course is unknown. The study aim was to evaluate humoral immune response in ALS patients during disease progression. Circulating immune complexes (CICs), IgG, and IgM in sera of ALS patients and matching controls were evaluated after each of two visits. Results showed significantly elevated CICs and IgG in ALS patient sera. CICs decreased to control levels at the second visit, yet IgG remained higher than controls. Serum IgM was within normal range. Results suggest a humoral immune response initiating adaptive immunity in ALS, however, cellular immune response needs verification.
在肌萎缩侧索硬化症（ALS）中，有证据表明免疫反应参与疾病发病机制。尽管免疫变化指向适应性免疫反应，但在疾病过程中体液免疫或细胞免疫反应何者占主导尚不清楚。本研究旨在评估ALS患者疾病进展过程中的体液免疫反应。在两次就诊时分别对ALS患者和匹配的对照组血清中的循环免疫复合物（CIC）、IgG和IgM进行评估。结果显示，ALS患者血清中的CIC和IgG显著升高。第二次就诊时CIC降至对照水平，但IgG仍高于对照组。血清IgM在正常范围内。结果表明，体液免疫反应在ALS中启动了适应性免疫，然而，细胞免疫反应有待验证。
Zotero 插件