Department of Rheumatology, University Hospital of Brasília, Brasília, Brazil.
Autoimmun Rev. 2010 Feb;9(4):207-10. doi: 10.1016/j.autrev.2009.08.003. Epub 2009 Aug 13.
The Wnt signaling pathways play a key role in cell renewal, and there are two such pathways. In patients with rheumatoid arthritis (RA), the synovial membrane expresses genes such as Wnt and Fz at higher levels than those observed in patients without RA. The Wnt proteins are glycoproteins that bind to receptors of the Fz family on the cell surface. The Wnt/Fz complex controls tissue formation during embryogenesis, as well as throughout the process of limb development and joint formation. Recent studies have suggested that this signaling pathway plays a role in the pathophysiology of RA. Greater knowledge of the role of the Wnt signaling pathway in RA could improve understanding of the differences in RA clinical presentation and prognosis. Further studies should also focus on Wnt family members as molecular targets in the treatment of RA.
Wnt 信号通路在细胞更新中起着关键作用，其中有两条这样的通路。在类风湿关节炎（RA）患者中，滑膜膜表达的基因（如 Wnt 和 Fz）的水平高于非 RA 患者。Wnt 蛋白是糖蛋白，它们与细胞表面 Fz 家族的受体结合。Wnt/Fz 复合物在胚胎发生过程中以及肢体发育和关节形成过程中控制组织形成。最近的研究表明，该信号通路在 RA 的病理生理学中起作用。更多地了解 Wnt 信号通路在 RA 中的作用，可以更好地理解 RA 临床表现和预后的差异。进一步的研究还应集中在 Wnt 家族成员作为 RA 治疗的分子靶点上。
