Anderson William S, Kiyofuji Satoshi, Conway James E, Busch Chris, North Richard B, Garonzik Ira M
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Neurosurgery. 2009 Sep;65(3):E626; discussion E626. doi: 10.1227/01.NEU.0000349211.01111.8A.
We report on a patient with a neuropathic facial pain syndrome, including elements of trigeminal neuralgia, glossopharyngeal neuralgia, and dysphagia. After failing medical and surgical decompressive treatments, the patient underwent implantation of a motor cortex stimulation (MCS) system.
A 54-year-old woman presented with a 14-year history of left-sided facial pain, throat pain, and associated nausea and vomiting. The patient failed several open surgical and percutaneous procedures for her facial pain syndrome. Additionally, several medication trial attempts were unsuccessful. Imaging studies were normal.
The patient underwent placement of a right-sided MCS system for treatment of her neuropathic facial pain syndrome. The procedure was tolerated well, and the trial stimulator provided promising results. The permanent MCS generator needed to be reprogrammed at the time of the 5-week follow-up visit to optimize symptom relief. The patient demonstrated dramatic improvements in her neuropathic facial and oral pain, including improvements in swallowing toleration, after the 5-week follow-up examination with subthreshold MCS. A decline in treatment efficacy also occurred 2 years after implantation due to generator depletion. Symptom improvement returned with stimulation after the generator was replaced.
A novel implantable MCS system was used to treat this patient's neuropathic facial pain. Durable improvements were noted not only in her facial pain, but also in swallowing toleration. The ultimate role of MCS in the treatment of pain conditions is still not well-defined but might play a part in refractory cases and, as in this case, might improve other functional issues, including dysphagia.
我们报告一例患有神经性面部疼痛综合征的患者,该综合征包含三叉神经痛、舌咽神经痛及吞咽困难的症状。在药物和手术减压治疗均失败后,该患者接受了运动皮层刺激(MCS)系统植入术。
一名54岁女性,有14年左侧面部疼痛、咽痛及相关恶心呕吐病史。该患者针对其面部疼痛综合征进行的多次开放性手术和经皮手术均告失败。此外,多次药物试验尝试也未成功。影像学检查结果正常。
该患者接受了右侧MCS系统植入术,以治疗其神经性面部疼痛综合征。手术耐受性良好,试验刺激器取得了有前景的结果。在5周随访时,需要对永久性MCS发生器进行重新编程,以优化症状缓解效果。在5周亚阈值MCS随访检查后,患者神经性面部和口腔疼痛有显著改善,包括吞咽耐受性提高。植入后2年,由于发生器电量耗尽,治疗效果出现下降。更换发生器后,刺激治疗症状再次改善。
一种新型可植入MCS系统被用于治疗该患者的神经性面部疼痛。不仅其面部疼痛得到了持久改善,吞咽耐受性也有所提高。MCS在疼痛疾病治疗中的最终作用仍未明确界定,但可能在难治性病例中发挥作用,如本病例所示,还可能改善包括吞咽困难在内的其他功能问题。