Noipayak Pongsak
Department of Pediatrics, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Bangkok, Thailand.
J Med Assoc Thai. 2009 Aug;92(8):1040-5.
To compare 2D:4D ratios of autistic to non-autistic children as a risk factor of autism.
A hospital based case-control study was conducted from March 2007 to July 2008. Demographic data and general risk factors of autism had been collected using questionnaires from case and age matched control subjects aged 18 months to 15 years. Length of 2nd and 4th digits was measured by an electronic digital caliper.
The ratio of right hand 2D:4D of autistic children was 0.99 +/- 0.06 compared with 1.02 +/- 0.04 of non-autistic children (p = 0.01). On the other hand, 2D:4D ratio of left hand of autistic children was 0.99 +/- 0.07 while the ratio of non-autistic children was 1.01 +/- 0.03 (p = 0.04). The 2D:4D ratio of both hands between 0.96 and 1.01 were risk factors of autism with odds ratio between 3.22 and 5.35 (p < 0.05).
The ratios of 2D:4D of both hands of autistic children were lower [corrected] than non-autistic children. The ratios of 2D:4D between 0.96 and 1.01 of both hands associated with an increased risk of autism in children aged 18 months to 15 years.
比较自闭症儿童与非自闭症儿童的2D:4D比例，将其作为自闭症的一个风险因素。
于2007年3月至2008年7月开展了一项基于医院的病例对照研究。通过问卷调查收集了年龄在18个月至15岁的病例组和年龄匹配的对照组受试者的人口统计学数据及自闭症的一般风险因素。使用电子数字卡尺测量第二和第四指的长度。
自闭症儿童右手的2D:4D比例为0.99±0.06，而非自闭症儿童为1.02±0.04（p = 0.01）。另一方面，自闭症儿童左手的2D:4D比例为0.99±0.07，而非自闭症儿童为1.01±0.03（p = 0.04）。双手2D:4D比例在0.96至1.01之间是自闭症的风险因素，比值比在3.22至5.35之间（p < 0.05）。
自闭症儿童双手的2D:4D比例低于非自闭症儿童。双手2D:4D比例在0.96至1.01之间与18个月至15岁儿童患自闭症的风险增加相关。
Zotero 插件