延髓腹侧头端胆碱能机制在疼痛诱导的镇痛中作用
Rostral ventral medulla cholinergic mechanism in pain-induced analgesia.
作者信息
Gear Robert W, Levine Jon D
机构信息
Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143-0440, United States.
出版信息
Neurosci Lett. 2009 Oct 30;464(3):170-2. doi: 10.1016/j.neulet.2009.08.036. Epub 2009 Aug 20.
Abstract
The ascending nociceptive control (ANC), a novel spinostriatal pain modulation pathway, mediates a form of pain-induced analgesia referred to as noxious stimulus-induced antinociception (NSIA). ANC includes specific spinal cord mechanisms as well as circuitry in nucleus accumbens, a major component of the ventral striatum. Here, using the trigeminal jaw-opening reflex (JOR) in the rat as a nociceptive assay, we show that microinjection of the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine into the rostral ventral medulla (RVM) blocks NSIA, implicating RVM as a potentially important link between ANC and the PAG-RVM-spinal descending pain modulation system. A circuit connecting nucleus accumbens to the RVM is proposed as a novel striato-RVM pathway.
摘要
上行伤害性控制（ANC）是一种新型的脊髓纹状体疼痛调制通路，介导一种被称为伤害性刺激诱导的抗伤害感受（NSIA）的疼痛诱导镇痛形式。ANC包括特定的脊髓机制以及伏隔核（腹侧纹状体的主要组成部分）中的神经回路。在此，我们利用大鼠的三叉神经张口反射（JOR）作为伤害感受测定方法，发现向延髓头端腹内侧区（RVM）微量注射烟碱型乙酰胆碱受体（nAChR）拮抗剂美加明可阻断NSIA，这表明RVM可能是ANC与PAG-RVM-脊髓下行疼痛调制系统之间的重要联系。一条连接伏隔核与RVM的神经回路被认为是一条新型的纹状体-RVM通路。
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