Beubler E, Coupar I M, Hardcastle J, Hardcastle P T
Department of Biomedical Science, The University, Sheffield, UK.
J Pharm Pharmacol. 1990 Jan;42(1):35-9. doi: 10.1111/j.2042-7158.1990.tb05345.x.
The rise in transmural potential difference (PD) and the fluid secretion induced by 5-hydroxytryptamine (5-HT) were measured in rat small intestine in-vivo. Both cisapride and ketanserin abolished the 5-HT-induced rise in systolic blood pressure mediated by 5-HT2 receptors. Cisapride inhibited the 5-HT-induced increases in the transintestinal PD, but over the same dose range it had no effect on the fluid secretion induced by 5-HT. In contrast, ketanserin caused a dose-dependent reduction in 5-HT-induced fluid secretion at doses that failed to influence the rise in PD. It is concluded that different receptors are responsible for the effects of 5-HT on fluid secretion and electrical activity in the rat small intestine.
在大鼠小肠体内测量跨壁电位差（PD）的升高以及5-羟色胺（5-HT）诱导的液体分泌。西沙必利和酮色林均消除了由5-HT2受体介导的5-HT诱导的收缩压升高。西沙必利抑制5-HT诱导的跨肠PD升高，但在相同剂量范围内，它对5-HT诱导的液体分泌没有影响。相反，酮色林在未能影响PD升高的剂量下，使5-HT诱导的液体分泌呈剂量依赖性减少。得出的结论是，不同的受体负责5-HT对大鼠小肠液体分泌和电活动的影响。
