Lin Chia-Yu, Huang Chin-Shiu, Huang Chun-Yin, Yin Mei-Chin
Department of Health and Nutrition Biotechnology, Asia University, Taichung County, Taiwan, ROC.
J Agric Food Chem. 2009 Aug 12;57(15):6661-7. doi: 10.1021/jf9015202.
Content of protocatechuic acid (PA) in eight locally available fresh fruits was analyzed, and the protective effects of this compound in diabetic mice were examined. PA at 1%, 2%, and 4% was supplied to diabetic mice for 8 weeks. PA treatments significantly lowered plasma glucose and increased insulin levels. PA treatments at 2% and 4% significantly lowered plasminogen activator inhibitor-1 activity and fibrinogen level; increased plasma activity of antithrombin-III and protein C; decreased triglyceride content in plasma, heart, and liver; elevated glutathione level and the retention of glutathione peroxidase and catalase activities in heart and kidney. PA treatments at 2% and 4% also significantly lowered plasma C-reactive protein and von Willebrand factor levels and reduced interleukin-6, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1 levels in heart and kidney. These results support that protocatechuic acid could attenuate diabetic complications via its triglyceride-lowering, anticoagulatory, antioxidative, and antiinflammatory effects.
分析了八种当地可得新鲜水果中原儿茶酸（PA）的含量，并检测了该化合物对糖尿病小鼠的保护作用。将1%、2%和4%的PA给予糖尿病小鼠，持续8周。PA处理显著降低了血糖水平并提高了胰岛素水平。2%和4%的PA处理显著降低了纤溶酶原激活物抑制剂-1活性和纤维蛋白原水平；提高了抗凝血酶III和蛋白C的血浆活性；降低了血浆、心脏和肝脏中的甘油三酯含量；提高了谷胱甘肽水平以及心脏和肾脏中谷胱甘肽过氧化物酶和过氧化氢酶的活性保留率。2%和4%的PA处理还显著降低了血浆C反应蛋白和血管性血友病因子水平，并降低了心脏和肾脏中白细胞介素-6、肿瘤坏死因子-α和单核细胞趋化蛋白-1的水平。这些结果支持原儿茶酸可通过其降低甘油三酯、抗凝、抗氧化和抗炎作用减轻糖尿病并发症。
