GPR30/GPER1：探寻其在雌激素生理学中的作用

GPR30/GPER1: searching for a role in estrogen physiology.

作者信息

Olde Björn, Leeb-Lundberg L M Fredrik

机构信息

Unit of Drug Target Discovery, Department of Experimental Medical Science, Lund University, SE-22184 Lund, Sweden.

出版信息

Trends Endocrinol Metab. 2009 Oct;20(8):409-16. doi: 10.1016/j.tem.2009.04.006. Epub 2009 Sep 4.

DOI:10.1016/j.tem.2009.04.006

PMID:19734054

Abstract

Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular and immune systems.

摘要

雌激素是对两性健康和疾病都至关重要的性激素。长期以来，人们认识到这些激素通过相对缓慢的基因组机制和快速的非基因组机制以复杂的方式发挥作用。最近的几项体外研究表明，GPR30或G蛋白偶联雌激素受体1（GPER1）是一种参与非基因组雌激素信号传导的功能性膜雌激素受体。然而，这一功能并未得到普遍认可。关于GPER1在体内作用的研究现在开始出现，但结果不一。在这篇综述中，我们讨论了目前关于GPER1在神经系统、生殖、代谢、骨骼以及心血管和免疫系统中的生理作用的知识。