Epidemiology Unit, Ministry of Health, No. 231, de Saram Place, Colombo 10, Sri Lanka.
Int J Infect Dis. 2010 May;14(5):e372-6. doi: 10.1016/j.ijid.2009.06.018. Epub 2009 Sep 6.
To demonstrate the burden of Haemophilus influenzae type b (Hib) disease in Sri Lanka and provide information for decision-making in public health planning and vaccine introduction.
This was a prospective, population-based study carried out in 2004, to describe the epidemiology and calculate the incidence of meningitis caused by Hib in children <5 years of age in the district of Colombo, Sri Lanka. Hib was identified in cerebrospinal fluid (CSF) specimens by culture and antigen detection (latex agglutination test; LAT).
The lumbar puncture rate in children <5 years of age was 1.9%. A causative bacterial organism was identified in 108 meningitis cases, and in 54 (50%) this was Hib. The LAT increased the Hib detection rate in CSF four-fold. In 2004, the annual incidence of Hib meningitis in Colombo was 20.1 cases per 100000 children aged <5 years.
This study is the first from Sri Lanka reporting the Hib meningitis incidence rate pre-vaccine introduction. The reported incidence rate is one of the highest from the Asian region, but is likely an underestimation considering the difficulties in the laboratory identification of Hib.
展示乙型流感嗜血杆菌（Hib）疾病在斯里兰卡的负担，并为公共卫生规划和疫苗接种决策提供信息。
这是一项在 2004 年进行的前瞻性、基于人群的研究，旨在描述科伦坡地区 5 岁以下儿童中由 Hib 引起的脑膜炎的流行病学，并计算其发病率。通过培养和抗原检测（乳胶凝集试验；LAT）从脑脊液（CSF）标本中鉴定 Hib。
5 岁以下儿童腰椎穿刺率为 1.9%。在 108 例脑膜炎病例中，有 108 例确定了致病细菌，其中 54 例（50%）为 Hib。LAT 将 CSF 中 Hib 的检测率提高了四倍。2004 年，科伦坡 Hib 脑膜炎的年发病率为每 100000 名 5 岁以下儿童 20.1 例。
这是斯里兰卡首例报告疫苗接种前 Hib 脑膜炎发病率的研究。报告的发病率是亚洲地区最高的之一，但考虑到 Hib 的实验室鉴定困难，这可能是低估了发病率。
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