Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University, Indiana, USA.
Antioxid Redox Signal. 2010 Jun 1;12(11):1247-69. doi: 10.1089/ars.2009.2698.
Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair is the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in its role as a redox factor. APE1 is reduced by the general redox factor thioredoxin, and in turn reduces several important transcription factors that regulate expression of DNA repair proteins. Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair.
氧化还原反应被认为可以调节许多重要的细胞过程。在这篇综述中,我们重点讨论了氧化还原调节在 DNA 修复中的作用,包括对特定 DNA 修复蛋白的直接调节以及间接的转录调节。在 DNA 修复的氧化还原调节中,碱基切除修复酶脱嘌呤/脱嘧啶内切酶 1(APE1)是一个关键的酶,它作为一个氧化还原因子发挥作用。APE1 被一般的氧化还原因子硫氧还蛋白还原,反过来又还原几种重要的转录因子,这些转录因子调节 DNA 修复蛋白的表达。最后,我们考虑了通过调节 APE1 的氧化还原活性及其对 DNA 修复的影响来开发化疗药物的潜力。