Desai Rani A, Manley Melinda, Desai Mayur M, Potenza Marc N
Department of Psychiatry, Yale University, New Haven, CT 06516, USA.
CNS Spectr. 2009 Jul;14(7):372-83. doi: 10.1017/s1092852900023026.
The objective of the study was to examine gender differences in the relationship between weight group (under-weight to severely obese), and Axis I and Axis II psychopathology.
Data from the National Epidemiologic Survey of Alcohol and Related Conditions (NESARC) were analyzed. Logistic regression models examined the past-year likelihood for meeting diagnostic criteria for psychiatric disorders. Interactions between weight group and gender were utilized to determine whether associations were significantly different in men and women after adjusting for demographic characteristics.
First, consistent with previous NESARC analyses, the prevalence estimates of psychiatric disorders were higher among people of higher body mass index groups, regardless of gender. However, these patterns differed across genders. Both severely obese women and men, in comparison to normal weight respondents, were much more likely to meet criteria for affective and anxiety disorders, but these associations were significantly (1.5-2 times) stronger among women. For Axis II disorders, while there were very few associations between personality disorders and weight in men, among women increases in weight group were associated with increases in the likelihood of meeting criteria for a personality disorder.
Weight and psychopathology appear more strongly associated in women than in men. While these data do not allow for identification of underlying mechanisms, they highlight the importance of assessing for psychopathology in overweight and obese patients, and suggest that weight management may be an important consideration in the treatment of psychiatric disorders.
本研究的目的是探讨体重组(从体重过轻到严重肥胖)与轴I和轴II精神病理学之间关系中的性别差异。
对来自全国酒精及相关疾病流行病学调查(NESARC)的数据进行分析。逻辑回归模型检验了过去一年达到精神障碍诊断标准的可能性。利用体重组与性别的相互作用来确定在调整人口统计学特征后,男性和女性之间的关联是否存在显著差异。
首先,与之前的NESARC分析一致,无论性别如何,体重指数较高人群中精神障碍的患病率估计值更高。然而,这些模式在不同性别之间存在差异。与正常体重的受访者相比,严重肥胖的女性和男性更有可能符合情感和焦虑障碍的标准,但这些关联在女性中显著更强(1.5至2倍)。对于轴II障碍,虽然男性中人格障碍与体重之间的关联很少,但在女性中,体重组的增加与符合人格障碍标准的可能性增加有关。
体重与精神病理学在女性中的关联似乎比在男性中更强。虽然这些数据无法确定潜在机制,但它们突出了对超重和肥胖患者进行精神病理学评估的重要性,并表明体重管理可能是精神障碍治疗中的一个重要考虑因素。