具有免疫抑制作用的睡茄凝内酯。

Immunosuppressive withanolides from Withania coagulans.

机构信息

Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 199 Guoshoujing Road, Shanghai 201203, P. R. China.

出版信息

Chem Biodivers. 2009 Sep;6(9):1415-26. doi: 10.1002/cbdv.200800211.

DOI:10.1002/cbdv.200800211

PMID:19774603

Abstract

Six new withanolides, withacoagulins A-F (1-6, resp.), together with ten known withanolides, 7-16, were isolated from the aerial parts of Withania coagulans. Their structures were determined by spectroscopic techniques including 1D- and 2D-NMR (1H, 13C, HMQC, and HMBC) and MS experiments. These compounds, including the crude extracts of this herb, exhibited strong inhibitory activities on the T- and B-cell proliferation.

摘要

从 Withania coagulans 的地上部分分离得到了 6 个新的醉茄内酯，即 withacoagulins A-F（1-6），以及 10 个已知的醉茄内酯，7-16。通过光谱技术，包括 1D 和 2D-NMR（1H、13C、HMQC 和 HMBC）和 MS 实验，确定了它们的结构。这些化合物，包括这种草药的粗提取物，对 T 细胞和 B 细胞增殖有很强的抑制活性。