格雷夫斯病合并自主功能性甲状腺结节：病例报告。

Graves' disease with an autonomously functioning thyroid nodule: case report.

作者信息

Jabrocka-Hybel Agata, Gołkowski Filip, Bałdys-Waligórska Agata, Sokołowski Grzegorz, Hubalewska-Dydejczyk Alicja

机构信息

Department of Endocrinology, Jagiellonian University School of Medicine, Kraków, Poland.

出版信息

Pol Arch Med Wewn. 2009 Jul-Aug;119(7-8):505-8.

PMID:19776692

Abstract

We present the case of a 68-year-old woman with Graves' disease, orbitopathy and an autonomously functioning thyroid nodule. Initially, the patient was diagnosed with orbitopathy as a sign of euthyroid Graves-Basedow's disease, confirmed by the presence of thyrotropin receptor antibodies. Five years later symptoms of hyperthyroidism occurred. Thyroid scan with iodine-131 (131I) showed a hot nodule in the right lobe. Recurrences of hyperthyroidism and short remissions were observed in the course of the disease - the symptoms typical of hyperthyroidism due to an autonomously functioning thyroid nodule. Fine needle aspiration biopsy of the nodule revealed no atypical follicular cells and the patient was scheduled for 131I treatment. She has been euthyroid for over one year.

摘要

我们报告一例68岁患有格雷夫斯病、眼眶病和自主功能性甲状腺结节的女性病例。最初，患者被诊断为眼眶病，作为甲状腺功能正常的格雷夫斯-巴塞多氏病的体征，促甲状腺素受体抗体的存在证实了这一诊断。五年后出现了甲状腺功能亢进症状。用碘-131（131I）进行的甲状腺扫描显示右叶有一个热结节。在疾病过程中观察到甲状腺功能亢进的复发和短暂缓解——这是自主功能性甲状腺结节导致的甲状腺功能亢进的典型症状。结节的细针穿刺活检未发现非典型滤泡细胞，患者被安排接受131I治疗。她甲状腺功能正常已超过一年。