(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.

Suppr

超能文献

作者信息

DeNinno M P, Schoenleber R, Asin K E, MacKenzie R, Kebabian J W

机构信息

Neuroscience Research, Pharmaceutical Discovery, Abbott Laboratories, Abbott Park, Illinois 60064.

出版信息

J Med Chem. 1990 Nov;33(11):2948-50. doi: 10.1021/jm00173a005.

DOI:10.1021/jm00173a005

PMID:1977907

Abstract

摘要

相似文献

(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.

J Med Chem. 1990 Nov;33(11):2948-50. doi: 10.1021/jm00173a005.

Comparison of the D1-dopamine agonists SKF-38393 and A-68930 in neonatal 6-hydroxydopamine-lesioned rats: behavioral effects and induction of c-fos-like immunoreactivity.

J Pharmacol Exp Ther. 1992 Aug;262(2):855-65.

A68930: a potent agonist selective for the dopamine D1 receptor.

Eur J Pharmacol. 1991 Jun 25;199(2):209-19. doi: 10.1016/0014-2999(91)90459-4.

A68930: a potent and specific agonist for the D-1 dopamine receptor.

Am J Hypertens. 1990 Jun;3(6 Pt 2):40S-42S. doi: 10.1093/ajh/3.6.40s.

Neurobiology of D1 dopamine receptors after neonatal-6-OHDA treatment: relevance to Lesch-Nyhan disease.

Adv Exp Med Biol. 1986;204:197-215. doi: 10.1007/978-1-4684-5191-7_13.

Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.

J Med Chem. 1991 Aug;34(8):2561-9. doi: 10.1021/jm00112a034.

New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.

J Med Chem. 1997 Dec 19;40(26):4235-56. doi: 10.1021/jm9703653.

(+/-)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepin, a new high-affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship.

J Med Chem. 1991 Dec;34(12):3366-71. doi: 10.1021/jm00116a004.

A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets.

Eur J Pharmacol. 1992 Dec 15;229(2-3):203-9. doi: 10.1016/0014-2999(92)90556-j.

Effects of D1 and D2 dopamine receptor stimulation on the activity of substantia nigra pars reticulata neurons in 6-hydroxydopamine lesioned rats: D1/D2 coactivation induces potentiated responses.

Brain Res. 1987 Mar 10;405(2):234-46. doi: 10.1016/0006-8993(87)90293-9.

引用本文的文献

Role of Dopamine in the Heart in Health and Disease.

Int J Mol Sci. 2023 Mar 6;24(5):5042. doi: 10.3390/ijms24055042.

Dopamine and Dopamine-Related Ligands Can Bind Not Only to Dopamine Receptors.

Life (Basel). 2022 Apr 19;12(5):606. doi: 10.3390/life12050606.

Copper-catalysed enantioselective intramolecular etherification of propargylic esters: synthetic approach to chiral isochromans.

RSC Adv. 2019 Jun 17;9(33):18918-18922. doi: 10.1039/c9ra03880a. eCollection 2019 Jun 14.

The Discovery of Novel Selective D1 Dopaminergic Agonists: A-68930, A-77636, A-86929, and ABT-413.

Int J Med Chem. 2011;2011:424535. doi: 10.1155/2011/424535. Epub 2011 Mar 24.

Investigation of D₁ receptor-agonist interactions and D₁/D₂ agonist selectivity using a combination of pharmacophore and receptor homology modeling.

ChemMedChem. 2012 Mar 5;7(3):483-94, 338. doi: 10.1002/cmdc.201100546. Epub 2012 Feb 7.

Brain dopamine receptors: 20 years of progress.

Neurochem Res. 1993 Jan;18(1):101-4. doi: 10.1007/BF00966928.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验