Department of Veterinary Clinical Medicine and College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.
Domest Anim Endocrinol. 2010 Feb;38(2):95-102. doi: 10.1016/j.domaniend.2009.08.004. Epub 2009 Sep 17.
The response to oral glucose was examined in 10 obese and 9 lean age-matched, neutered cats. In all cats, oral administration of 2g/kg glucose was followed by a prompt increase in glucose, insulin, and glucagon-like peptide (GLP)-1. There were significant differences between lean and obese cats in the areas under the curve for glucose, insulin, and GLP-1. However, the responses were variable, and a clear distinction between individual lean and obese cats was not possible. Therefore, this test cannot be recommended as a routine test to examine insulin resistance in individual cats as it is used in people. A further disadvantage for routine use is also the fact that this test requires gastric tubing for the correct administration of the glucose and associated tranquilization to minimize stress and that it was associated with development of diarrhea in 25% of the cats. GLP-1 concentrations were much lower in obese than lean cats. The low GLP-1 concentrations in obese cats might indicate a contribution of GLP-1 to the lower insulin sensitivity of obese cats, but this hypothesis needs to be further investigated.
我们检测了 10 只肥胖猫和 9 只同龄、去势、体重正常的猫对口服葡萄糖的反应。所有猫在口服 2g/kg 葡萄糖后，血糖、胰岛素和胰高血糖素样肽-1（GLP-1）迅速升高。在肥胖猫和正常猫之间，血糖、胰岛素和 GLP-1 的曲线下面积存在显著差异。然而，反应是可变的，无法明确区分个体肥胖猫和正常猫。因此，不能像在人群中那样将该测试推荐为常规测试来检查个体猫的胰岛素抵抗。该测试的另一个缺点是，为了正确给予葡萄糖和相关镇静剂以最大程度地减少应激，需要进行胃管饲，并且该测试与 25%的猫发生腹泻有关。肥胖猫的 GLP-1 浓度明显低于体重正常的猫。肥胖猫中 GLP-1 浓度较低可能表明 GLP-1 有助于肥胖猫的胰岛素敏感性降低，但这一假说需要进一步研究。
