RhoA的破坏促进肌动蛋白的形成。
Destruction of RhoA CULtivates actin.
作者信息
Wu Shuangding, Wolf Dieter A
机构信息
Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.
出版信息
Mol Cell. 2009 Sep 24;35(6):735-6. doi: 10.1016/j.molcel.2009.09.012.
Abstract
Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation, thereby maintaining actin cytoskeleton integrity.
摘要
Cullin 3是CRL3泛素连接酶家族的核心亚基，对发育至关重要，但其底物仍不清楚。在此，Chen等人（2009年）报告称，CRL3（BACURD）靶向RhoA GTP酶进行降解，从而维持肌动蛋白细胞骨架的完整性。
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