Institute for Biomedical Sciences of Pain, Capital Medical University, Beijing 100069, China.
Neurosci Bull. 2009 Oct;25(5):237-66. doi: 10.1007/s12264-009-0905-4.
Pain is a complex experience consisting of sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Now it has been gradually known that noxious information is processed by a widely-distributed, hierarchically- interconnected neural network, referred to as neuromatrix, in the brain. Thus, identifying the multiple neural networks subserving these functional aspects and harnessing this knowledge to manipulate the pain response in new and beneficial ways are challenging tasks. Albeit with elaborate research efforts on the cortical responses to painful stimuli or clinical pain, involvement of the hippocampal formation (HF) in pain is still a matter of controversy. Here, we integrate previous animal and human studies from the viewpoint of HF and pain, sequentially representing anatomical, behavioral, electrophysiological, molecular/biochemical and functional imaging evidence supporting the role of HF in pain processing. At last, we further expound on the relationship between pain and memory and present some unresolved issues.
疼痛是一种复杂的体验，包括感觉辨别、情感动机和认知评价三个维度。现在已经逐渐认识到，有害信息是由大脑中一个广泛分布、层次互联的神经网络处理的，这个神经网络被称为神经基质。因此，确定这些功能方面所涉及的多个神经网络，并利用这些知识以新的有益方式来操纵疼痛反应是具有挑战性的任务。尽管人们对皮质对疼痛刺激或临床疼痛的反应进行了精心的研究，但海马结构（HF）在疼痛中的作用仍然存在争议。在这里，我们从 HF 和疼痛的角度综合了以前的动物和人类研究，依次呈现支持 HF 在疼痛处理中作用的解剖学、行为学、电生理学、分子/生物化学和功能成像证据。最后，我们进一步阐述了疼痛和记忆之间的关系，并提出了一些尚未解决的问题。
