结外 NK/T 细胞淋巴瘤鼻型：培门冬酶的疗效。来自美国的两例患者报告及文献复习。
Extranodal NK/T-cell lymphoma nasal type: efficacy of pegaspargase. Report of two patients from the United Sates and review of literature.
出版信息
Leuk Res. 2010 Jan;34(1):e50-4. doi: 10.1016/j.leukres.2009.09.002. Epub 2009 Sep 27.
Abstract
Extranodal NK/T cell lymphoma nasal type is an EBV driven non-Hodgkin lymphoma, rare in the United States, with no known satisfactory treatment. Two patients with this entity refractory to CHOP chemotherapy responded to single agent pegaspargase (pegylated L-asparaginase). A 64-year-old Caucasian woman presented with extranodal NK/T lymphoma nasal type on her left buttocks. After initial treatment with loco-regional irradiation and CHOP, she developed extensive lower extremity lesions, and subsequent paranasal sinus involvement. With pegaspargase, she had a dramatic improvement of her skin lesions and proceeded to autologous stem cell transplant. A 48 year old Asian man presented with nasal cavity extranodal NK/T lymphoma which resolved with radiation therapy. Multiple liver lesions which developed while receiving CHOP completely resolved on pegaspargase. L- Asparaginase and its pegylated form have activity in this disease and further exploration alone or in combination is warranted.
摘要
结外 NK/T 细胞淋巴瘤鼻型是一种 EBV 驱动的非霍奇金淋巴瘤，在美国较为罕见，目前尚无已知的满意治疗方法。2 例对 CHOP 化疗耐药的该病患者对单药培门冬酶（聚乙二醇化 L-门冬酰胺酶）有反应。1 例 64 岁白人女性左侧臀部出现结外 NK/T 淋巴瘤鼻型。最初接受局部区域放疗和 CHOP 治疗后，她出现广泛的下肢病变，随后累及副鼻窦。使用培门冬酶后，她的皮肤病变明显改善，并进行了自体干细胞移植。1 例 48 岁亚裔男性患有鼻腔结外 NK/T 淋巴瘤，经放疗后缓解。在接受 CHOP 治疗期间出现的多个肝病变在使用培门冬酶后完全消退。门冬酰胺酶及其聚乙二醇化形式在这种疾病中有活性，单独或联合进一步探索是合理的。
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