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[静脉滥用透皮芬太尼后发生严重非致命性中毒——一例报告]

[Severe nonfatal poisoning after intravenous abuse of transdermal fentanyl--a case report].

作者信息

Magdalan Jan

机构信息

Oddział Toksykologiczny Dolnoślaskiego, Szpitala Specjalistycznego im. T. Marciniaka we Wrocławiu.

出版信息

Przegl Lek. 2009;66(6):341-2.

Abstract

Fentanyl is a potent synthetic opioid with short-acting analgesic activity after intravenous or subcutaneous administration. The potency and lipid solubility of fentanyl make it suitable for delivery via the transdermal therapeutic system in the treatment of chronic pain. In this paper a case of nonfatal, severe poisoning after intravenous injection of the content from four transdermal patches (Durogesic 75 microg/h) in the 18-year-old male opiate abuser is presented. The present case demonstrates the possibility of intravenous abuse of transdermal patches and the risk of severe intoxication. In the cases of suspected fentanyl overdose specific assays should be utilized for the detection of fentanyl because it may not be detected by the routine opiate screening procedure.

摘要

芬太尼是一种强效合成阿片类药物,静脉或皮下给药后具有短效镇痛活性。芬太尼的效力和脂溶性使其适用于通过透皮治疗系统给药以治疗慢性疼痛。本文介绍了一名18岁男性阿片类药物滥用者静脉注射四个透皮贴剂(多瑞吉75微克/小时)内容物后发生非致命性严重中毒的病例。本病例表明了静脉滥用透皮贴剂的可能性以及严重中毒的风险。在疑似芬太尼过量的情况下,应采用特定检测方法来检测芬太尼,因为常规阿片类药物筛查程序可能无法检测到它。

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