Department of General, Visceral, and Pediatric Surgery, Heinrich-Heine-University and University Hospital Düsseldorf, D-40225 Düsseldorf, Germany.
Int J Cancer. 2010 Feb 1;126(3):589-98. doi: 10.1002/ijc.24916.
Recent genetic analyses of paired samples from primary tumours and disseminated tumour cells have uncovered a bewildering genetic disparity. It was therefore proposed that ectopically residing tumour cells disseminate early and develop independently into metastases parallel to the primary tumour. Alternatively, these cells may represent an irrelevant cell population unable to spawn metastases whereas only cells that disseminated late in primary tumour development (which therefore are similar to the primary tumour) will form manifest metastasis. Here, we review comparative analyses of paired samples from primary tumours and disseminated tumour cells or primary tumours and metastases. The data demonstrate a striking disparity, questioning the use of primary tumours as surrogate for the genetics of systemic cancer. In the era of molecular therapies that build upon genetic defects of tumour cells, these data call for a direct diagnostic pathology of systemic cancer.
最近对原发性肿瘤和播散性肿瘤细胞配对样本的遗传分析揭示了令人困惑的遗传差异。因此，有人提出异位肿瘤细胞早期播散，并与原发性肿瘤平行独立地发展为转移。或者，这些细胞可能代表一种无关的细胞群体，无法产生转移，而只有在原发性肿瘤发展后期播散的细胞（因此与原发性肿瘤相似）才会形成明显的转移。在这里，我们回顾了原发性肿瘤和播散性肿瘤细胞或原发性肿瘤和转移瘤配对样本的比较分析。这些数据显示出明显的差异，质疑将原发性肿瘤作为系统性癌症遗传的替代物的做法。在基于肿瘤细胞遗传缺陷的分子治疗时代，这些数据呼吁对系统性癌症进行直接的诊断病理学研究。
