Immobilization of bis(bipyridine) BINOL ligands and their use in chiral resolution.

作者信息

Bunzen Jens, Kiehne Ulf, Benkhäuser-Schunk Christian, Lützen Arne

机构信息

Kekulé Institut für Organische Chemie und Biochemie, Rheinische Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

出版信息

Org Lett. 2009 Nov 5;11(21):4786-9. doi: 10.1021/ol901958v.

DOI:10.1021/ol901958v

PMID:19795874

Abstract

An enantiomerically pure bis(bipyridine) BINOL ligand was synthesized which was functionalized with an iodine substituent in its periphery. Using this halogen function, the ligand was immobilized on a commercially available polystyrene gel via Suzuki cross-coupling. The functionalized gel was found to be effective in the chiral resolution of similar bis(bipyridine) ligands based on a Tröger's base core.

摘要