Simşek Gökçe, Akın Istemihan, Köybaşıoğlu Fulya, Mutlu Murad, Onal Binnur, Günsoy Behçet
Department of Otolaryngology, Dişkapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2009 Mar-Apr;19(2):71-6.
In this study, we investigated the diagnostic value of fine needle aspiration cytology (FNAC) in salivary gland masses retrospectively. We compared FNAC and postoperative histopathologic results of patients who had undergone FNAC and had been operated on because of salivary gland masses.
Seventy six patients (40 females, 36 males; mean age 50.4 years; range 20 to 80 years) having salivary gland masses who underwent FNAC and surgical treatment between January 2001 and June 2008 were included in the study. Fine needle aspiration cytology and histopathologic results were compared retrospectively. The sensitivity, specificity, positive and negative predictive values and accuracy rate of the FNAC in salivary gland masses were evaluated in the light of the results.
The most common benign and malign FNAC results were pleomorphic adenoma (22 patients; 29.7%) and mucoepidermoid carcinoma (4 patients; 5.4%), respectively. Fine needle aspiration cytology results of two patients were non-diagnostic and these patients were excluded. According to the FNAC and histopathologic results of 74 patients, sensitivity was found to be 80.9%, specificity 94.3%, positive predictive value 85% and negative predictive value 92.5% and accuracy rate of FNAC 90.5%.
Fine needle aspiration cytology is a reliable method that has high sensitivity to distinguish between benign and malign salivary gland lesions. In case of suspicious FNAC reports, reliability and diagnostic value of the method is decreased.
在本研究中，我们回顾性调查了细针穿刺细胞学检查（FNAC）在涎腺肿物中的诊断价值。我们比较了接受FNAC检查并因涎腺肿物接受手术治疗的患者的FNAC结果与术后组织病理学结果。
纳入2001年1月至2008年6月间接受FNAC检查和手术治疗的76例涎腺肿物患者（40例女性，36例男性；平均年龄50.4岁；范围20至80岁）。回顾性比较细针穿刺细胞学检查结果和组织病理学结果。根据结果评估FNAC在涎腺肿物中的敏感性、特异性、阳性和阴性预测值以及准确率。
最常见的良性和恶性FNAC结果分别是多形性腺瘤（22例患者；29.7%）和黏液表皮样癌（4例患者；5.4%）。2例患者的细针穿刺细胞学检查结果无法诊断，这些患者被排除。根据74例患者的FNAC和组织病理学结果，发现敏感性为80.9%，特异性为94.3%，阳性预测值为85%，阴性预测值为92.5%，FNAC的准确率为90.5%。
细针穿刺细胞学检查是一种可靠的方法，对区分涎腺良性和恶性病变具有高敏感性。在FNAC报告可疑的情况下，该方法的可靠性和诊断价值会降低。
