Gaipl U S, Meister S, Lödermann B, Rödel F, Fietkau R, Herrmann M, Kern P M, Frey B
Department of Radiation Oncology, University of Erlangen-Nuremberg, D-91054, Erlangen, Germany.
Autoimmunity. 2009 May;42(4):340-2. doi: 10.1080/08916930902831233.
Low-dose radiation (single doses from 0.3 to 1.0 Gy) in clinical practice is mostly used to treat patients with several inflammatory diseases and painful degenerative disorders. Low-dose radiation is known to exert anti-inflammatory effects. However, the molecular and cellular mechanism are not fully analysed and most of the observed effects are based on empirical studies. We investigated the effects of low-dose radiation on the activation-induced cell death of polymorph nuclear granulocytes (PMN). A biphasic appearance of cell death in irradiated PMN was observed, displaying a relative maximum at 0.3 Gy and minimum at 0.5 Gy, respectively. This biphasic course of cell death was coincident with the protein level of total cellular Akt. We conclude that low-dose radiation exerts immunomodulatory effects on PMN contributing to the observed anti-inflammatory effects in clinical applications.
在临床实践中，低剂量辐射（单次剂量为0.3至1.0 Gy）主要用于治疗多种炎症性疾病和疼痛性退行性疾病患者。已知低剂量辐射具有抗炎作用。然而，其分子和细胞机制尚未得到充分分析，大多数观察到的效应基于实证研究。我们研究了低剂量辐射对多形核粒细胞（PMN）活化诱导细胞死亡的影响。在受辐照的PMN中观察到细胞死亡呈双相性，分别在0.3 Gy时出现相对最大值，在0.5 Gy时出现最小值。这种细胞死亡的双相过程与总细胞Akt的蛋白水平一致。我们得出结论，低剂量辐射对PMN发挥免疫调节作用，这有助于在临床应用中观察到的抗炎效果。
