Moss Celia
Department of Dermatology, Birmingham Children's Hospital, Birmingham, UK.
J Invest Dermatol. 2009 Nov;129(11):2543-5. doi: 10.1038/jid.2009.292.
Genetic disorders with skin manifestations often affect other organs as well, and diseases with a similar array of features might be linked pathogenetically. Classifying disorders by individual phenotypic components may reveal clusters with a common genetic cause and elucidate pathogenic links. If components are categorized inadequately, however, the method will simply confirm what is known, obscure true links, and suggest false ones.