患有镰状细胞病的儿童中，严重的头孢曲松诱导的溶血并发弥漫性脑缺血。
Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease.
作者信息
Schuettpelz Laura G, Behrens Deanna, Goldsmith Matthew I, Druley Todd E
机构信息
Division of Hematology and Oncology, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.
出版信息
J Pediatr Hematol Oncol. 2009 Nov;31(11):870-2. doi: 10.1097/MPH.0b013e3181b7eda2.
Ceftriaxone-induced hemolytic anemia is a rare and often fatal phenomenon. We report here the case of a 6-year-old female with sickle cell disease who survived a brisk and profound hemolytic reaction, resulting in hemoglobin of 0.4 g/dL, after ceftriaxone infusion. Ongoing hemolysis was abrogated with aggressive supportive care, but the patient suffered extensive neurologic sequelae as a result of the event. Serologic testing confirmed the presence of ceftriaxone antibodies.
头孢曲松诱导的溶血性贫血是一种罕见且常致命的现象。我们在此报告一例6岁患镰状细胞病的女性病例，该患者在输注头孢曲松后经历了迅速且严重的溶血反应，血红蛋白降至0.4 g/dL 仍存活。积极的支持治疗消除了持续的溶血，但患者因该事件出现了广泛的神经后遗症。血清学检测证实存在头孢曲松抗体。
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