Ueda Shiro, Minami Yoshihiko, Hara Yasuhito, Kawano Takahiro, Maekawa Katsuhide
Dept. of Surgery, Ohyodo General Hospital.
Gan To Kagaku Ryoho. 2009 Oct;36(10):1725-7.
We report a case of recurrent rectal cancer with multiple lung metastases successfully treated with S-1 and CPT-11 combination chemotherapy. Rectal amputation was carried out on the rectal cancer patient, a 63-year-old man. CT scan revealed multiple lung metastases after 20 months of surgery. The patient was treated with S-1 and CPT-11 combination chemotherapy. S-1(100mg/body/day)was orally administered for 2 weeks followed by a 1-week interval, and CPT-11 (120 mg/body on day 1)was simultaneously administered. After completion of 8 courses, CT scan showed no lung metastases, and the patient was judged to have achieved a complete response (CR). The CR interval was maintained for twelve months until 20 courses of chemotherapy had been completed. This chemotherapy was expected to have a potent therapeutic efficacy for recurrent rectal cancer, considering the convenience, cost benefit and no severe adverse event.
我们报告了一例复发性直肠癌伴多发肺转移的病例，该患者成功接受了S-1与CPT-11联合化疗。对一名63岁男性直肠癌患者实施了直肠切除术。术后20个月的CT扫描显示出现多发肺转移。该患者接受了S-1与CPT-11联合化疗。S-1（100mg/体/天）口服给药2周，随后间隔1周，同时在第1天给予CPT-11（120mg/体）。完成8个疗程后，CT扫描显示无肺转移，患者被判定达到完全缓解（CR）。CR期维持了12个月，直至完成20个疗程的化疗。考虑到便利性、成本效益以及无严重不良事件，这种化疗预期对复发性直肠癌具有强大的治疗效果。
