胰腺移植对糖尿病肾移植受者生活质量的影响。

Impact of pancreas transplantation on the quality of life of diabetic renal transplant recipients.

作者信息

Ziaja J, Bozek-Pajak D, Kowalik A, Król R, Cierpka L

机构信息

Department of General, Vascular, and Transplant Surgery, Medical University of Silesia, ul. Francuska 20-24, 40-027 Katowice, Poland.

出版信息

Transplant Proc. 2009 Oct;41(8):3156-8. doi: 10.1016/j.transproceed.2009.07.101.

DOI:10.1016/j.transproceed.2009.07.101

PMID:19857701

Abstract

UNLABELLED

Simultaneous pancreas and kidney transplantation (SPKT) is considered to be the best method of treatment for patients with chronic renal failure (CRF) resulting from insulin-dependent diabetes mellitus (IDDM). The aim of the study was to compare the quality of life (QOL) of patients with IDDM and CRF subjected to SPK or kidney transplantation alone (KTA).

MATERIALS AND METHODS

We analyzed 21 patients after SPKT with good function of both grafts. The results were compared with 17 patients with functioning kidney grafts. Minimal observation time was 6 months. QOL was evaluated using Kidney Disease and Quality of Life Short Form (KDQOL-SF), which was sent to recipients by post. Results were presented as medians and interquartile ranges of calculated scored KDQOL-SF points.

RESULTS

Observation time was 30 months (range, 6-85). Analyzed groups did not differ as regards patient age at transplantation or duration of diabetes and dialysis treatment before transplantation. After SPKT patients reported higher QOL compared with KTA as regards symptom/problem list, 90.91 (86.36-95.46) versus 84.09 (75.00-90.91; P = .04), effects of kidney disease, 90.63 (84.38-93.75) versus 81.25 (68.75-82.14; P = .001); cognitive function, 93.33 (86.67-100.00) versus 80.00 (73.33-93.33; P = .03); overall health, 80.00 (70.00-90.00) versus 50.00 (50.00-70.00; P = .001); physical functioning, 90.00 (75.00-100.00) versus 80.00 (55.00-85.00; P = .03); and pain, 100.00 (90.00-100.00) versus 67.50 (45.00-90.00; P = .005), respectively.

CONCLUSION

SPKT had a positive impact on selected parameters of QOL among patients with IDDM and CRF compared to KTA.

摘要

未标注

同时进行胰腺和肾脏移植（SPKT）被认为是治疗胰岛素依赖型糖尿病（IDDM）所致慢性肾衰竭（CRF）患者的最佳方法。本研究的目的是比较接受SPK或单纯肾脏移植（KTA）的IDDM和CRF患者的生活质量（QOL）。

材料与方法

我们分析了21例移植后移植物功能良好的SPKT患者。将结果与17例肾脏移植物功能正常的患者进行比较。最短观察时间为6个月。使用肾脏疾病与生活质量简表（KDQOL-SF）评估QOL，该问卷通过邮寄方式发送给受者。结果以计算得出的KDQOL-SF评分的中位数和四分位间距表示。

结果

观察时间为30个月（范围6 - 85个月）。分析的两组患者在移植时的年龄、糖尿病病程和移植前透析治疗时间方面无差异。与KTA相比，SPKT患者在症状/问题列表方面报告的QOL更高，分别为90.91（86.36 - 95.46）和84.09（75.00 - 90.91；P = 0.04）；肾脏疾病影响方面，分别为90.63（84.38 - 93.75）和81.25（68.75 - 82.14；P = 0.001）；认知功能方面，分别为93.33（86.67 - 100.00）和80.00（73.33 - 93.33；P = 0.03）；总体健康方面，分别为80.00（70.00 - 90.00）和50.00（50.00 - 70.00；P = 0.001）；身体功能方面，分别为90.00（75.00 - 100.00）和80.00（55.00 - 85.00；P = 0.03）；疼痛方面，分别为100.00（90.00 - 100.00）和67.50（45.00 - 90.00；P = 0.005）。