Farley J M, Dwyer T M
Department of Physiology University of Mississippi Medical Center, Jackson 39216-4505.
Life Sci. 1991;48(1):59-67. doi: 10.1016/0024-3205(91)90425-b.
Muscarinic stimulation of mucus secretion, as measured by the release of [3H]glycoprotein, was studied in explants from the tracheal epithelium of weanling swine. The mucus glycoprotein secretion was transient, ceasing within the first 10 min of a continuous exposure to 100 microM ACh. Increasing the solution's osmotic pressure did not alter basal mucus glycoprotein secretion. Mucus glycoprotein secretion was inhibited by 2-10 microM PZP, indicating that the M3 muscarinic receptors mediate cholinergic stimulation of mucus production.
