阿瑟氏现象：兔脑局部过敏炎症。
THE ARTHUS PHENOMENON : LOCAL ANAPHYLACTIC INFLAMMATION IN THE RABBIT BRAIN.
机构信息
Departments of Neurology, Bacteriology, and Medicine, College of Physicians and Surgeons of Columbia University, and The Presbyterian Hospital, New York.
出版信息
J Exp Med. 1932 Jan 1;55(1):163-8. doi: 10.1084/jem.55.1.163.
Abstract
- Sixteen out of seventeen rabbits actively sensitized to various antigens by repeated cerebral and intravenous injections showed upon intracerebral reinjection of the same antigen local anaphylactic inflammation of the brain at the site of inoculation. 2. Six out of twenty rabbits actively sensitized to either horse serum or egg albumen by extracerebral injections, showed, upon introduction of the homologous antigen into the cerebrum, local anaphylactic inflammation at the site of inoculation. 3. The pathological picture of the Arthus phenomenon in the brain of the rabbit resembled that seen in the skin, after allowing for differences in the fundamental structure of the tissues involved. 4. None of the control animals exhibited lesions comparable to those found in the experimental animals. A few controls showed slight hemorrhages due to mechanical injury of blood vessels. 5. Clinical symptoms of varying degrees of severity, often leading to the death of the rabbit were observed in the sensitized animals. These symptoms were referable to the site of injection.
摘要
17 只兔子中有 16 只通过反复脑内和静脉内注射各种抗原主动致敏，当将相同抗原再次脑内注射时，接种部位的脑局部发生过敏反应性炎症。
20 只兔子中有 6 只通过脑外注射主动致敏马血清或卵白蛋白，当同源抗原被引入大脑时，接种部位出现局部过敏反应性炎症。
兔脑 Arthus 现象的病理图像与皮肤相似，考虑到所涉及组织的基本结构的差异。
没有一只对照动物表现出与实验动物相同的病变。一些对照动物由于血管的机械损伤而出现轻微的出血。
在致敏动物中观察到不同严重程度的临床症状，这些症状常导致兔子死亡。这些症状与注射部位有关。
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本文引用的文献
1
THE ARTHUS PHENOMENON : LOCAL ANAPHYLACTIC INFLAMMATION IN THE RABBIT PERICARDIUM, HEART, AND AORTA.阿瑟斯现象：兔心包、心脏和主动脉局部过敏炎症。
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