Departments of Bacteriology and Medicine, The University of Rochester School of Medicine and Dentistry, Rochester, New York.
J Exp Med. 1943 Oct 1;78(4):321-6. doi: 10.1084/jem.78.4.321.
Intranasal instillation of herpes virus in suckling mice results in specific lesions widely distributed in the viscera. The lungs are infected by aspiration of the virus. Virus disseminated by way of the blood establishes itself in endothelium in certain situations where parenchymal lesions result by direct spread from the vascular foci. Evidence of blood-borne infection was found frequently in the liver and spleen, less frequently in the suprarenals, and, in one instance, in the bone marrow. Renal infection appeared to be uriniferous. Lymph carriage of the virus also occurs, and lymph nodes draining infected areas were often found to contain herpetic inclusion bodies. Herpes virus seems incapable of invading the central nervous system of suckling mice by the vascular route.
滴鼻感染乳鼠可使病毒广泛分布于内脏器官,引起特异性病灶。病毒可经肺内吸入而感染肺部。病毒经血流播散,在某些情况下,病毒可从血管病灶直接扩散至实质而引起病变。血源感染的证据,常常见于肝脏和脾脏,较少见于肾上腺,在一例中还见于骨髓。肾脏感染似属尿源型。病毒也可经淋巴传播,引流感染区的淋巴结常含有疱疹包涵体。单纯疱疹病毒似乎不能经血流侵犯乳鼠的中枢神经系统。