United States Navy Research Unit at the Hospital of The Rockefeller Institute for Medical Research.
J Exp Med. 1946 Jan 31;83(2):89-96.
It has been shown that extremely minute amounts of purified preparations of desoxyribonuclease are capable of bringing about the complete and irreversible inactivation of the transforming substance of Pneumococcus Type III. The significance of the effect of the enzyme, and its bearing on the chemical nature of the transforming substance, together with certain considerations concerning the biological specificity of desoxyribonucleic acids in general, are discussed.
已证明,极微量的纯化脱氧核糖核酸酶制剂就能使 III 型肺炎球菌转化物质完全不可逆地失活。本文讨论了该酶的作用意义及其对转化物质化学本质的关系,以及一般脱氧核糖核酸的生物特异性的某些考虑。