哺乳动物血红蛋白中波尔效应的本质和意义。
The Nature and Significance of the Bohr Effect in Mammalian Hemoglobins.
机构信息
Zoology Department, The University of Texas, Austin.
出版信息
J Gen Physiol. 1960 Mar 1;43(4):737-52. doi: 10.1085/jgp.43.4.737.
Abstract
The oxygenation of hemoglobins is accompanied by the dissociation of protons. The number of protons discharged is inversely related to the size of the mammal from which the hemoglobin comes. The number of mercuric ions which are immediately bound by hemoglobins is approximately equal to the number of protons dissociated during oxygenation. Pretreatment of human hemoglobin by N-ethylmaleimide, which appears to bind only sulfhydryl groups prevents the binding of any mercuric ions under conditions when mercuric ions would otherwise be bound. These facts suggest that those mammals with higher metabolic rates will generally possess hemoglobins with a larger number of appropriately placed cysteine residues.
摘要
血红蛋白的氧合伴随着质子的离解。释放的质子数量与血红蛋白来源的哺乳动物的大小成反比。汞离子与血红蛋白的立即结合数量大约等于氧合过程中离解的质子数量。用似乎只结合巯基的 N-乙基马来酰亚胺预处理人血红蛋白，可防止在汞离子本来会结合的情况下结合任何汞离子。这些事实表明，那些代谢率较高的哺乳动物通常具有具有更多适当位置半胱氨酸残基的血红蛋白。
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本文引用的文献
1
A method for the micro-estimation of iron in biological materials.
Biochem J. 1941 Jun;35(5-6):672-5. doi: 10.1042/bj0350672.
2
Further studies on the oxygen equilibrium of hemoglobin.
J Biol Chem. 1950 Nov;187(1):393-410.
3
On the cysteine content of human hemoglobin.
J Biol Chem. 1958 Dec;233(6):1359-63.
4
Oxygen dissociation curves of mammalian blood in relation to body size.
Am J Physiol. 1958 Nov;195(2):424-8. doi: 10.1152/ajplegacy.1958.195.2.424.
5
The thiol groups of normal adult human haemoglobin.
Biochem J. 1958 May;69(1):27-34. doi: 10.1042/bj0690027.
6
Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin.
Nature. 1957 Aug 17;180(4581):326-8. doi: 10.1038/180326a0.
7
The equilibrium between cytochrome oxidase and carbon monoxide.
J Gen Physiol. 1957 Mar 20;40(4):593-608. doi: 10.1085/jgp.40.4.593.
8
Sulfhydryl groups and the structure of hemoglobin.
J Gen Physiol. 1956 Mar 20;39(4):585-605. doi: 10.1085/jgp.39.4.585.
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