α,α-海藻糖单晶中的伴随脱水机制。
Concomitant dehydration mechanisms in single crystals of alpha,alpha-trehalose.
机构信息
La2B-SMS UPRES EA3233, Centre Universitaire d'Evreux, Université de Rouen, Evreux Cedex, France.
出版信息
Carbohydr Res. 2009 Dec 14;344(18):2539-46. doi: 10.1016/j.carres.2009.09.032. Epub 2009 Oct 2.
The dehydration behaviour of alpha,alpha-trehalose (alpha-D-glucopyranosyl alpha-D-glucopyranoside) dihydrate single crystals is investigated by thermomicroscopy, Raman microscopy, and differential scanning calorimetry. The results show at a given stage the simultaneous presence of two polymorphic forms, amorphous material, and movement of a fluid phase. The study also underlines that the characterization of the average phase by conventional XRPD and DSC techniques is not sufficient to describe the dehydration mechanisms of alpha,alpha-trehalose particles. Moreover, it confirms that the dehydration behaviour is mainly driven by heterogeneities and the rate of water loss.
采用热显微镜、拉曼显微镜和差示扫描量热法研究了α，α-海藻糖（α-D-吡喃葡萄糖基-α-D-吡喃葡萄糖苷）二水合物单晶的脱水行为。结果表明，在给定阶段同时存在两种多晶型形式、无定形物质和流相移动。该研究还强调，通过常规 X 射线粉末衍射和差示扫描量热技术对平均相的表征不足以描述α，α-海藻糖颗粒的脱水机制。此外，它证实了脱水行为主要是由不均匀性和失水速率驱动的。
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