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[辛德毕斯病毒与产生肿瘤病毒的细胞培养物的相互作用]

[Interaction of Sindbis virus with a culture of cells producing oncornavirus].

作者信息

Gushchin B V, Berezina L K, Gushchina E A, L'vov D K, Klimenko S M

出版信息

Vopr Virusol. 1977 May-Jun(3):326-31.

PMID:198967
Abstract

Electron microscopy and biophysical methods were used for examinations of primarily trypsinized chick fibroblast cell culture spontaneously producing C-type oncornavirus at 1, 6, and 24 hours after inoculation with Sindbis virus. During the first 6 hours rapid maturation and release of oncornavirus from cells were observed. At later intervals oncornavirus production was inhibited. It is assumed that in the system under study, biosynthesis of oncornavirus and Sindbis virus occur separately.

摘要

利用电子显微镜和生物物理方法,对接种辛德毕斯病毒后1小时、6小时和24小时自发产生C型肿瘤病毒的经胰蛋白酶初步处理的鸡成纤维细胞培养物进行检测。在最初的6小时内,观察到肿瘤病毒从细胞中快速成熟并释放。在随后的时间段,肿瘤病毒的产生受到抑制。据推测,在所研究的系统中,肿瘤病毒和辛德毕斯病毒的生物合成是分开进行的。

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