基质金属蛋白酶组织抑制因子C末端片段在麦迪逊-达比犬肾上皮细胞顶端和基底外侧的出现情况。
The occurrence of matriptase C-terminal fragments on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells.
作者信息
Tsuzuki Satoshi, Miyake Yuka, Inouye Kuniyo, Fushiki Tohru
机构信息
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
出版信息
Biosci Biotechnol Biochem. 2009 Nov;73(11):2538-40. doi: 10.1271/bbb.90431. Epub 2009 Nov 7.
Matriptase is a type II transmembrane serine protease. In the present study, matriptase C-terminal fragments containing the catalytic serine protease domain were found to occur on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells transfected with a cDNA encoding the protease. This suggests that matriptase interacts with various potential substrates when expressed in simple epithelia.
胃蛋白酶原激活肽酶是一种II型跨膜丝氨酸蛋白酶。在本研究中，发现含有催化性丝氨酸蛋白酶结构域的胃蛋白酶原激活肽酶C末端片段出现在用编码该蛋白酶的cDNA转染的Madin-Darby犬肾上皮细胞的顶端和基底外侧。这表明胃蛋白酶原激活肽酶在简单上皮细胞中表达时与各种潜在底物相互作用。
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