Giessing M
Klinik für Urologie, Heinrich-Heine-Universitätsklinikum, Moorenstrasse 5, 40225, Düsseldorf, Deutschland.
Urologe A. 2009 Dec;48(12):1429-37. doi: 10.1007/s00120-009-2155-5.
On 1 January 1999 Eurotransplant started the "Eurotransplant Senior Program" (ESP), the first program worldwide for age-matched kidney allocation and transplantation of expanded criteria donors (ECD). By now more than 4.300 kidneys from donors aged > or =65 were transplanted into recipients > or =65, with local or regional allocation according only to blood group compatibility and waiting time. Compared to ongoing dialysis, renal transplantation in the ESP offers longer patient survival and improved quality of life. The article evaluates the results of the ESP and of other studies dealing with renal transplantation of old donor kidneys into aged recipients. Specific aspects like the unexpectedly high acute rejection rate and ways to assess the residual renal function of aged donor kidneys are covered as well as the specific post-transplant risks of aged recipients.
1999年1月1日，欧洲器官移植组织启动了“欧洲器官移植老年项目”（ESP），这是全球首个针对年龄匹配的肾脏分配以及扩大标准供体（ECD）肾脏移植的项目。截至目前，已有超过4300个来自65岁及以上供体的肾脏被移植到65岁及以上的受者体内，仅根据血型相容性和等待时间进行本地或区域分配。与持续透析相比，ESP项目中的肾移植能为患者提供更长的生存期并改善生活质量。本文评估了ESP项目以及其他关于将老年供体肾脏移植给老年受者的研究结果。文中还探讨了一些具体问题，如意外高的急性排斥率、评估老年供体肾脏残余肾功能的方法，以及老年受者移植后的特定风险。
