Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ 85721, USA.
Ann Biomed Eng. 2010 Jan;38(1):164-76. doi: 10.1007/s10439-009-9833-8. Epub 2009 Nov 10.
An aneurysm is a gradual and progressive ballooning of a blood vessel due to wall degeneration. Rupture of abdominal aortic aneurysm (AAA) constitutes a significant portion of deaths in the US. In this study, we describe a technique to reconstruct AAA geometry from CT images in an inexpensive and streamlined fashion. A 3D reconstruction technique was implemented with a GUI interface in MATLAB using the active contours technique. The lumen and the thrombus of the AAA were segmented individually in two separate protocols and were then joined together into a hybrid surface. This surface was then used to obtain the aortic wall. This method can deal with very poor contrast images where the aortic wall is indistinguishable from the surrounding features. Data obtained from the segmentation of image sets were smoothed in 3D using a Support Vector Machine technique. The segmentation method presented in this paper is inexpensive and has minimal user-dependency in reconstructing AAA geometry (lumen and wall) from patient image sets. The AAA model generated using this segmentation algorithm can be used to study a variety of biomechanical issues remaining in AAA biomechanics including stress estimation, endovascular stent-graft performance, and local drug delivery studies.
动脉瘤是由于血管壁退化导致的血管逐渐和渐进性的膨胀。腹主动脉瘤(AAA)破裂在美国构成了大量死亡的原因。在这项研究中,我们描述了一种从 CT 图像中以廉价且精简的方式重建 AAA 几何形状的技术。使用主动轮廓技术在 MATLAB 中实现了具有图形用户界面的 3D 重建技术。AAA 的管腔和血栓分别在两个单独的协议中进行分割,然后合并成一个混合表面。然后,使用该表面获得主动脉壁。该方法可以处理对比度非常差的图像,其中主动脉壁与周围特征难以区分。使用支持向量机技术对图像集的分割数据进行了 3D 平滑处理。本文提出的分割方法在从患者图像集中重建 AAA 几何形状(管腔和壁)方面成本低廉且对用户的依赖性最小。使用此分割算法生成的 AAA 模型可用于研究 AAA 生物力学中仍存在的多种生物力学问题,包括应力估计、血管内支架移植性能和局部药物输送研究。